Modified on: February 27th, 2023

Overview

This report provides exploratory and preliminary correlation analyses between sex hormones and T2 final hippocampal subfield volume data from the Healthy Aging Study sample that have completed the spatial navigation study.

Cleaning data steps included (T2 subfields):

  1. Filter participants that have useable T2 subfield data from scan and completed spatial navigation behavior

  2. Select sex hormone measures from when spatial study was conducted

  3. Values were already averaged together (left and right) and already corrected with TIV

For left and right subfields, they have already been corrected with TIV

Calculating Total Hippocampal Volume:

  • Sum up the averaged CA1, CA23, DG, SUB to get T2 total hippocampal volumes

  • Left and right volumes are by adding respective left and right subfields

Calculating Total MTL:

  • Sum up the averaged CA1, CA23, DG, SUB, ERC, PHC, PRC to get MTL volume

  • Left and right volumes are by adding respective left and right subfields

Sample size and age for women and men grouped by overall completion of LOOP behavior with useable T2 hipp data.
Sex n Mean Age SD Age
Female 15 50.27 3.26
Male 11 49.18 2.93

Above table shows the table of sample size and mean and standard deviation of age by sex for overall group who have completed spatial behavior and have a useable T2hipp scan.

Behavioral Distributions

Shapiro-Wilk’s test reveal that LOOP degrees traveled at 3.0m for men and averaged angular error for overall and for men were not normally distributed. Behavior and volume correlations will be Spearman rank

Total Hippocampal Volume

Behavioral Correlations

LOOP

Position Error

All correlations are Pearson

LEFT

Degrees Traveled - 3.0m

All correlations were Pearson except for men (Spearman)

LEFT

All correlations were Pearson except for men (Spearman)

RIGHT

All correlations were Pearson except for men (Spearman)

Degrees Traveled - Averaged

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Angular Error - 3.0m

All correlations were Pearson

LEFT

RIGHT

All correlations were Pearson

Angular Error - Averaged

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

MTL

Behavioral Correlations

LOOP

Position Error

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Degrees Traveled - 3.0m

All correlations are Pearson except for men (Spearman)

LEFT

All correlations are Pearson except for men (Spearman)

RIGHT

All correlations are Pearson except for men (Spearman)

Degrees Traveled - Averaged

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Angular Error - 3.0m

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

Al correlations are Pearson

Angular Error - Averaged

All correlations are Pearson except for men (Pearson)

LEFT

All correlations are Pearson except for men (Pearson)

RIGHT

All correlations are Pearson except for men (Pearson)

T2 Subfield Volume

CA1

Behavioral Correlations

LOOP

Position Error

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Degrees Traveled - 3.0m

All correlations were Spearman

LEFT

All correlations were Spearman

RIGHT

All correlations were Spearman

Degrees Traveled - Averaged

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Angular Error - 3.0m

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

Angular Error - Averaged

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

CA2/3

Behavioral Correlations

LOOP

Position Error

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Degrees Traveled - 3.0m

All correlations are Pearson except for men (Spearman)

LEFT

All correlations are Pearson except for men (Spearman)

RIGHT

All correlations are Pearson except for men (Spearman)

Degrees Traveled - Averaged

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Angular Error - 3.0m

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Angular Error - Averaged

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

DG

Behavioral Correlations

LOOP

Position Error

All correlations were Pearson

LEFT

All correlations are Pearson

RIGHT

Degrees Traveled - 3.0m

All correlations are Pearson except for men (Spearman)

LEFT

All correlations are Pearson except for men (Spearman)

RIGHT

All correlations are Pearson except for men (Spearman)

Degrees Traveled - Averaged

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Angular Error - 3.0m

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Angular Error - Averaged

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

ERC

Behavioral Correlations

LOOP

Position Error

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Degrees Traveled - 3.0m

All correlations were Pearson except for men

LEFT

All correlations were Pearson except for men

RIGHT

All correlations were Pearson except for men

Degrees Traveled - Averaged

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Angular Error - 3.0m

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Angular Error - Averaged

All correlations are Spearman except for men

LEFT

All correlations are Spearman except for men

RIGHT

All correlations are Spearman except for men

PHC

Behavioral Correlations

LOOP

Position Error

Overall and male correlations were Pearson, female and repo groups were Spearman.

LEFT

Overall and male correlations were Pearson, female and repo groups were Spearman.

RIGHT

Overall and male correlations were Pearson, female and repo groups were Spearman.

Degrees Traveled - 3.0m

Overall correlation was Pearson, rest were Spearman.

LEFT

All correlations were spearman except for overall

RIGHT

All correlations were Spearman except for overall

Degrees Traveled - Averaged

Overall and male correlations were Pearson, female and repo groups were Spearman.

LEFT

Overall and male correlations were Pearson, female and repo groups were Spearman.

RIGHT

Overall and male correlations were Pearson, female and repo groups were Spearman.

Angular Error - 3.0m

Overall and male correlations were Pearson, female and repo groups were Spearman.

LEFT

Overall and male correlations were Pearson, female and repo groups were Spearman.

RIGHT

Overall and male correlations were Pearson, female and repo groups were Spearman.

Angular Error - Averaged

Overall and male correlations were Pearson, female and repo groups were Spearman.

LEFT

Overall and male correlations were Pearson, female and repo groups were Spearman.

RIGHT

Overall and male correlations were Pearson, female and repo groups were Spearman.

PRC

Behavioral Correlations

LOOP

Position Error

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Degrees Traveled - 3.0m

All correlations were Pearson except for men

LEFT

All correlations were Pearson except for men

RIGHT

All correlations were Pearson except for men

Degrees Traveled - Averaged

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Angular Error - 3.0m

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Angular Error - Averaged

All correlations are Spearman except for men

LEFT

All correlations are Spearman except for men

RIGHT

All correlations are Spearman except for men

SUB

Behavioral Correlations

LOOP

Position Error

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Degrees Traveled - 3.0m

All correlations were Pearson except for men

LEFT

All correlations were Pearson except for men

RIGHT

All correlations were Pearson except for men

Degrees Traveled - Averaged

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Angular Error - 3.0m

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Angular Error - Averaged

All correlations were Spearman except for men

LEFT

All correlations were Spearman except for men

RIGHT

All correlations were Spearman except for men

Summary

Sample included HAS participants who had a T2 hipp scan and completed spatial navigation behavior for LOOP.

Total hipp Volume and MTL

  • LOOP greater degrees traveled (3.0m and averaged) was significantly negatively correlated with lower total hipp volume within overall (women and men together) for averaged, left, and right volumes.

  • For men, total hipp volume was negatively correlated with degrees traveled averaged for averaged, left, and right volumes. Averaged totla hipp volume was only negatively correlated with degrees traveled at 3.0m for the average volume.

  • For women, total hipp volume was negatively correlated with degrees traveled at 3.0m for averaged and left total hipp volumes. Left total hipp volume was negatively correlated with degrees traveled averaged for women.

Subfields

  • LOOP position error was significantly negatively correlated with lower PHC volume within overall (women and men).

  • LOOP greater degrees traveled at 3.0m and averaged was significantly negatively correlated with lower volumes in CA1, CA23, DG, and SUB for overall. For men, negative correlations are observed for DG only at 3.0m, but seen in CA1, CA23, and DG for degrees traveled averaged. For women, negative correlations are observed for CA1, CA23, and SUB for 3.0m, and only for CA1 and CA23 for degrees traveled averaged.